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Nystagmus (repeated, involuntary, and jerky movements of the eyes) Lethargy, sedation, and/or sleepiness Problems with motor coordination Staggering gait Tremors (uncontrollable shaking in the legs or arms) Low blood pressure Nausea and/or vomiting Very slow and/or slurred speech Respiratory suppression Coma Overdose SeverityEstimated Reading Time: 6 mins. Phenytoin's ability to suppress these areas may result in impaired memory and balance, respectively. Paradoxically, very high levels of phenytoin may be associated with seizures. Acute oral overdose is usually manifested by nystagmus, nausea and vomiting, ataxia, and CNS depression. Deaths from oral ingestion of phenytoin are extremely rare. Aug 12, · Phenytoin displays its main signs of toxicity on the nervous and cardiovascular systems. Overdose on oral phenytoin causes mainly neurotoxicity and only very rarely causes cardiovascular toxicity. On the other hand, cardiovascular toxicity is the main side effect of parenteral administration. Neurotoxicity. Read More...
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