Something: Protein disorders
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Protein disorders Video
Susan Lindquist (Whitehead Institute, MIT, HHMI): Protein Folding and DiseaseAmyloid fibrils are deposits of proteins in the body that join together to form microscopic fibres. Until today, scientists have been unable to reliably measure the speed of fibril growth, as there have been no tools that could directly measure growth rate in solution.
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Most experimental techniques for measuring fibril growth in solution only measure how fast proteins transform into fibril material protein disorders, not how long each fibril is or how fast it is growing. Other techniques measure just one fibril attached to a surface such as glass or mica.
These conditions do not reflect the real biological process, which occurs in solution.
Researchers for the protein disorders study used Small Angle Neutron Scattering SANS to study the growth rate and length of amyloid fibrils as they assembled in solution. This gave a direct measurement of the growth rate, which had never been done before.
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The results of growth rate from this study align protein disorders values estimated from other methods, indicating that SANS is protein disorders suitable tool for measuring amyloid fibril growth. The technique also allowed the researchers to measure the number of fibril ends present in a given sample. This information told them how many separate fibres were growing, and the length of each one. The fragility of fibrils from different proteins, and how often they break into shorter fragments exposing more growing ends, is a key part of the puzzle to understand fibril disease propagation.
Understanding the growth of amyloid fibrils is fundamental to understanding their pathogenic, biological and technological properties. Notify me of follow-up comments by email. Notify me of new posts by email.
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