Unique properties of stem cells Video
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To better understand the mechanisms and regulatory pathways involved in cardiac hypertrophy, there is a need for improved in vitro models. In this study, we investigated how hypertrophic stimulation affected human induced pluripotent stem cell iPSC -derived cardiomyocytes CMs. The cells were stimulated with endothelin-1 ET-1 for 8, 24, 48, 72, or 96 h. Moreover, transcriptional profiling using RNA-sequencing was performed to identify differentially expressed genes following ET-1 stimulation. Furthermore, the lactate concentration in the media was increased indicating that the CMs consume more glucose, a hallmark of cardiac hypertrophy.Opinion, actual: Unique properties of stem cells
| WHO INVENTED ELECTRONIC CIGARETTES | Apr 13, · Among various stem cells, the multipotency and self-renewal capacity make MSCs a promising candidate for WMI treatment (Ramos-Cabrer et al., ; Huang et al., ; Mine et al., ), which can be expatiated as many unique biological effects including self-recovery by producing growth factors and cytokines, regenerative repair, inherent. 4 days ago · Moreover, we discuss the influence of the physicochem. properties of liposomes on their interaction with cells, half-life, ability to enter tissues, and final fate in vivo. Finally, we describe some strategies developed to overcome limitations of the "first-generation" liposomes, and liposome-based drugs on the market and in clin. trials. 13 hours ago · PDF | On Apr 11, , Rania Hanafi and others published Immuno-Histochemical Study of the Potential Impact Effect of a Single Intra-Peritoneal Injection Dose of Cisplatin on Stem Cells . |
| Unique properties of stem cells | A myocyte is a muscle cell of the heart (cardiac muscle cell) or of smooth muscle. There are two specialized forms of myocytes with distinct properties: cardiac muscle cells, and smooth muscle cells.A skeletal muscle cell is long and threadlike with many nuclei and is instead called a muscle fiber. Muscle cells including myocytes and muscle fibers develop from myoblasts to form muscles in a Location: Muscle. Apr 13, · Among various stem cells, the multipotency and self-renewal capacity make MSCs a promising candidate for WMI treatment (Ramos-Cabrer et al., ; Huang et al., ; Mine et al., ), which can be expatiated as many unique biological effects including self-recovery by producing growth factors and cytokines, regenerative repair, inherent. 4 days ago · Stem cells can regulate the immune function by secreting specific cytokines (cytokines are substances that allow cells to communicate with other cells) which regulate the expression of inflammatory substances and downregulate the immune system. Thus, representing an improved immune response and overall better health. |
| THE BIRTHPLACE OF CIVILIZATION | 30 minutes ago · The sources of mesenchymal stromal cells (MSCs) for cell therapy trials are expanding, increasing the need for their characterization. Here, we characterized multi-donor, turbinate-derived MSCs (TB-MSCs) that develop from the neural crest, and compared them to bone marrow-derived MSCs (BM-MSCs). TB-MSCs had higher proliferation potential and higher self-renewal of colony forming cells. A myocyte is a muscle cell of the heart (cardiac muscle cell) or of smooth muscle. There are two specialized forms of myocytes with distinct properties: cardiac muscle cells, and smooth muscle cells.A skeletal muscle cell is long and threadlike with many nuclei and is instead called a muscle fiber. Muscle cells including myocytes and muscle fibers develop from myoblasts to form muscles in a Location: Muscle. 4 days ago · Stem cells can regulate the immune function by secreting specific cytokines (cytokines are substances that allow cells to communicate with other cells) which regulate the expression of inflammatory substances and downregulate the immune system. Thus, representing an improved immune response and overall better health. |
L-SNAs are highly modular nanoscale assemblies defined by a dense, upright radial arrangement of oligonucleotides around a liposomal core. Herein, we establish a set of L-SNA design rules by studying the biological and immunological properties of L-SNAs as a function of liposome composition.
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To achieve this, we synthesized liposomes where the lipid phosphatidylcholine headgroup was held constant, while the diacyl lipid tail chain length and degree of saturation were varied, using either 1,2-dioleylphosphatidylcholine DOPC1,2-dimyristoyl-phosphatidylcholine DMPC1,2-dipalmitoylphosphatidylcholine DPPCor 1,2-distearoyl-phosphatidylcholine DSPC. These studies show that the identity of the constituent lipid dictates the DNA loading, cellular uptake, serum stability, in vitro immunostimulatory activity, and in vivo lymph node accumulation of the L-SNA.
This difference is further amplified when using lysates from oxidized Py cells as a more potent antigen source, revealing synergy between the lysate preparation method and liposome composition in synthesizing immunotherapeutic L-SNAs. Together, this work shows that the biological properties and immunomodulatory activity of L-SNAs can be modulated by exchanging liposome components, providing another handle for the rational design of nanoscale immunotherapeutics.
Review ARTICLE
Synopsis The molecular identity of the lipids that comprise liposomal spherical nucleic acids modulates their biological properties and provides a handle for their rational design as cancer immunotherapeutics. Regarded as one of the more successful biomolecule packing systems to date, 1 liposomes are useful in a wide variety of biomedical applications, including drug delivery, 2,3 biosensing, 4,5 diagnostics, 6,7 gene delivery, 8 and immunomodulation. At temperatures exceeding the TC, liposomes exist in a liquid-crystalline phase, where the membrane is more fluid and the dynamics of unique properties of stem cells exchange are increased.
In general, the TC increases as the diacyl lipid chain length increases, due to increased van der Waals forces between the acyl chains. SNAs are a unique class of nucleic acid defined by the dense, highly oriented arrangement of oligonucleotides around a nanoparticle core.]
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