Membrane fusion virus - good topic
Bharat, T. Structural dissection of Ebola virus and its assembly determinants using cryo-electron tomography. Natl Acad. USA , — Hyatt, A. Ultrastructure of Hendra virus and Nipah virus within cultured cells and host animals. Microbes Infect. membrane fusion virusAdvanced Search Intracellular membrane fusion occurs with exquisite coordination and specificity.
https://digitales.com.au/blog/wp-content/custom/why-building-administrations-have-a-developing-business/new-kabul.php It is known that formation of complexes between SNAREs from apposed membranes is a prerequisite for lipid bilayer mixing; however, the biophysics and many details of SNARE function are still vague. Recent work indicates that the fusion process itself may comprise two stages and proceed via a hemifusion intermediate.
Introduction
Keywords: SNARELipid bilayer membrane fusion virus, Membrane fusionTransmembrane segmentHemifusion Introduction Eukaryotic cells contain numerous compartments that membrane fusion virus separated from the cytosol by a lipid bilayer. Exchange of lipids, metabolites or proteins across the lipid bilayer can occur through integral membrane proteins - as demonstrated for peroxisomes, mitochondria or chloroplasts. Within the endomembrane system, which includes the endoplasmic reticulum ERthe Golgi, endosomes and lysosomes, vesicles transport cargo between organelles and thus mediate exchange Bonifacino and Glick, ; Mellman and Warren, Generally, vesicle formation requires a conserved set of coat proteins that bind to cargo and induce membrane curvature.
At the same time, a vesicle must incorporate proteins that target it to the right compartment and enable it to fuse with the target compartment Fig. Fusion seems to involve a cascade in which a Rab-GTPase, together with tethering factors, mediates membrane contact, which is followed by SNARE pairing and lipid bilayer mixing. SNAREs seem to operate at all stages.
Data availability
They need to be incorporated into the right vesicle, interact with tethers, and are essential for tight membrane docking and bilayer mixing. Here, we focus primarily fusoin their role in exocytosis and organelle fusion. The crystal structures of link formed by fragments of synaptic and endosomal SNAREs have been solved Antonin et al.
A closer analysis shows that the coiled-coil structure is composed of 15 hydrophobic layers, and a central hydrophilic zero-layer containing the R- and Q-residues Sutton et al. The positions of the R and Q residues can be swapped among the different membrane fusion virus as long as the 3Q:1R ratio is maintained Katz and Brennwald, ; Graf et al.]
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