These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. The Altmetric Attention Score is a quantitative measure of the attention that a research article has rthics online.
Clicking on the donut icon will load a page at altmetric. Find more information on the Altmetric Attention Score and how the score is calculated. Herein, we show encouraging https://digitales.com.au/blog/wp-content/custom/general-motors-and-the-affecting-factors-of/buddhism-and-the-afterlife.php indicating that human cathelicidin LL37 can simultaneously block viral S1 and cloak ACE2. Intranasal administration of LL37 to C57 mice infected with adenovirus expressing human ACE2 either before or after pseudovirion invasion decreased lung infection.
The study identified a versatile antimicrobial peptide in humans as an inhibitor of SARS-CoV-2 attachment using dual mechanisms, thus providing a potential candidate for coronavirus disease COVID prevention and treatment. This article is part of the Antiviral Therapeutics special issue.
Figure 1. B IC 50 determination.
Download ET App:
The region of interest in the S1-treated group is magnified in the embedding graph. Figure 2. LL37 is shown in the red ribbon on the right. Salt bridges, hydrogen bonds, and hydrophobic interactions are shown in orange, yellow, and purple, respectively.
Post navigation
Figure 3. D Pseudovirion neutralization assay. Figure 4. LL37 treatment inhibits pseudovirion infection in mouse lungs. A Diagrammatic drawing depicting the pseudovirion-based mouse infection model. Adenovirus, Adv ; pseudovirion, Pv. In the sham group, the cells were treated with sterile PBS. D Protein bands of Flag-tag and His-tag in mouse ethixs. E Immunofluorescence microscopy revealing the inhibition of LL37 on pseudovirion infection in vivo.
Such files may be downloaded by article for research use if there is a public use license linked to the relevant article, that license may acs codes of ethics other uses. Jianqi Zhao and J. The computations were performed at the Pengcheng Laboratory.
Social Media
More by Cheng Wang. More by Shaobo Wang.
More by Daixi Li.]
I am final, I am sorry, would like to offer other decision.
In it something is. Now all became clear to me, I thank for the information.
It has touched it! It has reached it!
What touching a phrase :)