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Rachel Kaletsky, Coleen T. Dis Model Mech 7 July ; 3 : — Aging is characterized by general physiological decline over time. A hallmark of human senescence is the onset of various age-related afflictions including neurodegeneration, cardiovascular disease and cancer. Although environmental and stochastic factors undoubtedly contribute to the increased incidence of disease with age, recent studies suggest that intrinsic genetic determinants govern both life span and overall health. Significant progress has been made using model organisms, especially the nematode worm Caenorhabditis elegans , to delineate the genetic and biochemical pathways involved in aging to identify strategies for therapeutic intervention in humans. In this review, we discuss how C. Aging studies in mammals are challenging owing to relatively long life spans and a limited set of genetic tools that are capable of assessing the genome-wide changes associated with disease. By contrast, C. Genetic resources for C. gerontology journal articles.
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Researchers have identified molecular signatures of the aging process in mice, publishing their results today in the open-access eLife journal. Their analyses provide one of the most comprehensive characterisations of the molecular signatures of aging across diverse types of cells from different tissues in a mammal, and will aid future studies on aging and related topics. Gerontology journal articles leads to the decline of major organs and is the main risk factor for many diseases, including cancer, cardiovascular and neurodegenerative diseases. While previous studies jiurnal highlighted different hallmarks of the aging process, the underlying molecular and cellular mechanisms remain unclear.
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The TMS contains overannotated cells from 23 tissues and organs of male and female mice. The gerontology journal articles TMS gerontology journal articles mainly explored the cell-centric effects of aging, aiming to characterize changes in the composition of cell types within different tissues.
In the current gene-centric study, Zhang and colleagues focused on changes https://digitales.com.au/blog/wp-content/custom/a-simple-barcoding-system-has-changed-inventory/utilitarianism-capital-punishment.php gene expression that occur during the aging process across different cell types. Using the TMS data, they identified aging-dependent genes in 76 cell types from 23 tissues. They then characterized gernotology aging behaviors of these genes that were both shared among all cell types 'globally' and specific to different tissue cells.
The team then used this coordinated activity to develop a single-cell aging score based on the global aging genes. This new high-resolution aging score revealed that different tissue-cell types in the same animal can have a different aging status, shedding light on the diverse aging process across different types of cells. Your feedback will go directly to Science X editors.
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More information: Martin Jinye Zhang et al, Mouse aging cell atlas analysis reveals global and cell type specific aging signatures, eLife DOI: Provided by eLife. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.]
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