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Not all submitted comments are published. Please see our commenting policy for details. Question Do all triple-negative breast cancers adenid similar aggressiveness and response to treatment or does heterogeneity exist among triple-negative breast cancers secondary to histological type? Findings In this cohort study adenoid cystic patients with rare breast cancers, adenoid cystic carcinomas and metaplastic breast cancer had similar proportions of tumors that were triple negative Meaning These findings suggest that breast cancer histological type may be associated with overall survival, treatment response, and clinical course despite triple-negative receptor status.
Importance Triple-negative breast cancers are known collectively to demonstrate a more aggressive clinical course and earlier recurrence than cancers of other histological subtypes. However, the adenoid cystic on rare triple-negative breast cancers and the association of histological type with survival and risk of metastasis is sparse.
Confirmed cases of medullary carcinoma, adenoid cystic carcinoma, and metaplastic breast cancer were analyzed.
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Univariable analyses and multivariable Cox regression models were performed. Data analysis was performed from April to May Secondary outcomes included site of metastasis, effect of immunohistochemistry, adenoid cystic, and 2-year mortality. Results A total of patients with breast cancer mean [SD] age; Adenoid cystic carcinoma presented earlier in life, at a median interquartile range age of 53 years, compared with 62 years for patients with adenoid cystic carcinoma and 63 years for patients with metaplastic carcinoma.
The proportion of tumors with triple-negative immunohistochemistry varied by histological type for medullary carcinoma 57 patients [ Patients adenoid cystic adenoid cystic carcinoma were less likely to receive radiotherapy patients [ The 5-year OS rate was superior for patients with medullary The 5-year mortality rate for adenoid cystic carcinoma was 8. Conclusions and Relevance Nationally, over the course of 7 years, medullary carcinoma was most common and metaplastic carcinoma had the worst 5-year OS among aenoid rare histological breast cancer subtypes analyzed. Factors associated with a poor prognosis for metaplastic carcinoma included advanced stage, lung metastasis, older age, and not receiving chemotherapy or radiation cywtic. Future research focusing on rare subtypes of breast cancer is desirable and could inform the optimal management of these cysttic understudied carcinomas. Patients with triple-negative breast cancer have poor go here because they are not managed with adenoid cystic therapies such as endocrine therapy or ERBB2 adenoid cystic antagonists.
However, patients with triple-negative breast cancer who are treated with chemotherapy might exhibit worse outcomes than patients with other breast cancer subtypes. Although triple-negative breast cancers are medically managed as a single group, clinicopathologic heterogeneity exists among them. Gene expression analysis via DNA microarrays has allowed for the identification of intrinsic breast cancer subtypes such as basal-like breast cancer. Our analysis sought to investigate the degree of heterogeneity among triple-negative breast cancers by analyzing their clinical, pathological, and molecular features. Analysis of the National Cancer Database NCDB over the course of 7 years provides a large representative patient population for a thorough investigation of these rare triple-negative breast cancers.
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We sought to describe the clinical presentation and management of triple-negative breast cancers, adenoid cystic overall survival Adenoid cysticand investigate the association of the triple-negative histological subtype with metastasis for medullary carcinoma, adenoid cystic carcinoma, and metaplastic breast carcinoma.
Ethical approval for this cohort study was obtained from the Cleveland Clinic institutional review board. Thus, informed consent was not required or sought. We used an open cohort study design to here rare triple-negative breast cancers in the US from through as reported by the NCDB.
References
The information reported to the NCDB is collected cywtic more adenoid cystic Commission on Cancer—accredited medical institutions. Completeness of data is assessed annually before release. One patient had a missing follow-up time and was excluded from any survival analysis. The study size is reflective of cases meeting eligibility criteria based on histological diagnosis, year of diagnosis, and staging. NCDB cases diagnosed with a histologically rare breast carcinoma of triple-negative immunohistochemistry were eligible.]
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