Refworks Account Login. Open Collections. UBC Theses and Dissertations. Featured Collection. High levels of musculotendinous strain resulting from heavy lifting or obesity andrepetitive movements are risk factors for tendinopathy. Having identified a potential role of MMP2 in these laboratory models, acadwmy clinicalstudy was also conducted to evaluate the serum levels of MMPs and TIMPs in patients who hadexperienced Achilles tendon rupture. Cultured tendon cells, controlled by high frequency or high strain stimulation, simulating overuse,increased MMP2 mRNA expression.
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Collagen type I mRNA and protein levels were increased in culturedtendon cells by controlled mechanical stimulation with intermittent rest periods compared tocontinuous emmbrane stimulation. After two weeks of repetitivetendon loading, collagen intensity, measured by second source generation microscopy, wasdecreased in the flexor digitorum superficialis FDS tendon compared to the contralateral FDS tendonand healthy control FDS tendon, indicating damage or remodelling of the collagen in response tooveruse.
Structural changes were observed locally, combined with elevated tissue MMP2 protein levelssuggesting a possible contribution of MMP2 to the development of early collagen degradation. It is detectable inserum after 1 week of overuse, and high repetition number and high strain level are independentmodulators of MMP2 expression in tenocytes.
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However, MMP2 levels in serum decline to baseline after2 weeks in the animal model, and were downregulated compared to controls in patients with a moreAchilles tendon rupture. Further research into the specific processes of tendon injury and repair playedby MMP2 cwll warranted. Enhanced collagen type I synthesis by human tenocytessubjected to periodic in-vitromechanical stimulation. BMC Musculoskelet Disord.
Materials and Methods
Elise Huisman designed and carried out the experiments, designed the quantitative image analysis,performed the statistical analysis and wrote the manuscript. Alex Lu performed theimmunocytochemistry and designed and carried out the quantitative image analysis.
McCormackdesigned and administered the clinical protocol for screening patients and collecting human tendontissue and clinical data. Alex Scott conceived of the study, designed experiments and helped writingthe manuscript. All authors read and approved the final manuscript. Regional molecular and cellulardifferences in the female rabbit Achilles tendon complex: potential implications for understandingresponses to loading.]
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