Italian healthcare system pros and cons - consider
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Erenumab, a first-in-class monoclonal antibody targeting the calcitonin gene-related peptide pathway, was approved by the US Food and Drug Administration in for the prevention of migraine in adults. There is limited data available on its impact in real-world settings.
The study aim was to characterize the real-world treatment profiles, clinical outcomes, and healthcare resource utilization of patients prescribed erenumab from select major US headache centers. A retrospective chart review of patients with migraine treated with erenumab for at least 3 months across five major headache centers was conducted. Data was collected from patient charts between April and April and included patient and clinical characteristics, migraine medication use, and outpatient visits. The proe of the first prescription fill of erenumab was defined as the index date. The baseline period comprised the 3 months prior to the index date and the study period comprised the at least 3 months on erenumab treatment.
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Data from a total of patients with chronic migraine with a mean of 9. Patients had a mean of 5 preventive treatment failures prior to erenumab initiation. Patients used a mean of 2 preventive treatments excluding erenumab and sytsem acute treatments during baseline and study periods. The average number of monthly outpatient visits was 0.
Introduction
However, patients largely continued to be managed via a polypharmacy approach after erenumab initiation. This article is published with digital features, including a summary slide, to facilitate understanding of the article.
Migraine has been shown to be associated with reduced quality of life, functional impairment, reduced productivity, and high economic burden, highlighting the importance of having effective therapeutic strategies [ 34567 ]. Because of the heterogeneity of migraine characteristics and symptom profiles amongst patients, optimizing individualized treatment programs is challenging. Many of the available preventive therapies were not developed specifically for migraine and have limited efficacy and tolerability [ 8 ].
Earlier preventive italian healthcare system pros and cons options included non-specific therapies such as repurposed antiepileptic drugs, antihypertensives, antidepressants, and botulinum toxins [ 8 ]. More recently, monoclonal antibodies targeting the calcitonin gene-related peptide CGRP pathway were developed specifically for migraine and are now available for the preventive treatment of migraine in adults.]
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