Lupus mortality Video
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Kelsey Kloss. Black lupus patients have a far greater risk of stroke and ischemic heart disease IHD than other groups, and there are several lupus-specific symptoms that may predict stroke and heart disease in Black people with lupus, according to new research. Systemic lupus erythematosus SLE — the most common form of lupus — is a chronic disease that causes systemic inflammation in multiple organs, such as the skin, joints, kidneys, lungs, heart, and brain. Lupus is more common in Black, Asian, and Native American people than in white people and it is also often worse for these groups. In a new study presented at ACR Convergence , the annual meeting of the American College of Rheumatology, researchers collected data from the Georgia Lupus Registry, a group of lupus patients in Atlanta who are followed over time. Researchers matched lupus patients from to with other patients in the Georgia Hospital Discharge Database and National Death Index from to
lupus mortality
Background and aims: Patients with systemic lupus erythematosus SLE have a significantly higher incidence of atherosclerosis than the general population.
Introduction
Studies on atherosclerosis lee essay models specific for SLE patients are very limited. This study aimed to build a risk prediction model for atherosclerosis in SLE. Subsequently, differential expression analysis was carried out on 19 pairs of age-matched SLE patients with AT group or without Non-AT group atherosclerosis using peripheral venous blood.
We used logistic least absolute shrinkage and selection lupus mortality regression to select variables among differentially expressed DE genes and clinical features and utilized backward stepwise logistic regression to build an atherosclerosis risk prediction model with all 67 patients. The performance of the prediction model was evaluated by area under the lhpus AUCcalibration curve, and decision curve analyses. Results: The 67 patients had a median age of Pathway analyses revealed that the AT group had upregulated lupus mortality signaling, oxidative phosphorylation, and lupus mortality IL related pathways but downregulated T cell and B cell receptor signaling.
Keratin 10, age, and hyperlipidemia were selected as variables for the risk lupus mortality model. The prediction model had a higher net benefit in the decision curve analysis than that when predicting with age or hyperlipidemia only. Conclusions: We built an atherosclerotic luppus prediction model with one gene and two clinical factors. This model may greatly assist clinicians to identify SLE patients with atherosclerosis, especially asymptomatic atherosclerosis. Systemic lupus erythematosus SLE moratlity a chronic autoimmune disease lupus mortality affects multiple systems including the cardiovascular system 1.
The incidence of cardiovascular events in SLE patients is significantly higher than that in the general population 2 — 4. Among females aged 35—44 years, SLE patients are 50 times more likely to develop myocardial infarction than healthy control subjects 4.
Atherosclerosis is the main cause of CVD. Patients with SLE also exhibit a higher prevalence of atherosclerosis than the general population 89.
Original Research ARTICLE
In SLE, atherosclerosis is related to both traditional risk factors, such as age, sex, hyperlipidemia, and SLE-related features, such as disease duration, disease activity, and medications 3 High-throughput sequencing is currently being applied to investigate atherosclerosis in SLE 12 — Although some interesting findings have been reported, the number of studies is relatively small, and the biological pathways that contribute to the increased atherosclerosis in SLE are not fully understood.
Early identification of SLE patients with atherosclerosis, which is often asymptomatic at the lupud stage, is important for prevention of atherosclerosis progression and future CVD. However, traditional prediction models, such lupus mortality the Framingham risk score, largely underestimate the prevalence of atherosclerosis or cardiovascular events in SLE patients 15moralityand studies on specific prediction models for atherosclerosis in SLE patients are limited. Nevertheless, the https://digitales.com.au/blog/wp-content/custom/african-slaves-during-the-nineteenth-century/research-paper-on-entrepreneurship.php biomarkers were derived from a limited number of candidate biomarkers.
Thus, it remains unclear whether combinations of untested biomarkers or genes can achieve better prediction accuracy.]
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