The process of aging - remarkable, rather
Primates are among the longest-lived groups of mammals. It is a process that goes on over the entire adult life span of any living thing. Gerontology , the study of the aging process, is devoted to the understanding and control of all factors contributing to the finitude of individual life. It is not concerned exclusively with debility, which looms so large in human experience, but deals with a much wider range of phenomena. Every species has a life history in which the individual life span has an appropriate relationship to the reproductive life span and to the mechanism of reproduction and the course of development. How these relationships evolved is as germane to gerontology as it is to evolutionary biology. It is also important to distinguish between the purely physicochemical processes of aging and the accidental organismic processes of disease and injury that lead to death. the process of aging
About AAAMS
A team of researchers led by Professor Juan Carlos Izpisua Belmonte of the Salk Institute for Biological Studieshave demonstrated the ability to integrate human cells into animal tissue, and hope that this new development will allow them to understand a variety of human diseases as-well as address the worrying shortage of donor organs across the world.
See more studyChimeric contribution of human extended pluripotent stem cells to monkey embryos was published in the science journal Cell. Chimeric organisms are organisms that contain cells from two or more species, and could be useful for "advancing biomedical research not just at the the process of aging earliest stage of life, but also the latest" said Izpisau Belmonte in a statement about his research. Using technology published in by Professor Weizhi Ji of Kunming University of Science and Technology in Yunnan, China, the research the process of aging tagged human pluripotent stem cells and inserted them into macaque embryos in petri dishes.
Browse by Topic
Each experiment was examined for 19 days before termination, and scientists observed that the human stem cells survived and integrated into the embryos with relative efficiency. Under the leadership of Izpisau Belmonte, a similar experiment was conducted in during which human cells were incorporated into early stage pig tissue. Whilst the research was groundbreaking at the time, the contribution of human cells was relatively low, which scientists attributed to the 90 million year evolutionary distance between the two species.
The macaque, with a 30 million year evolutionary distance, is more closely related to the modern human and so Izpisau Belmonte turned his team's attention there, hoping to further improve the chimera formation through the old world monkey species. Izpisau Belmonte compared the process of cell integration to people communicating in different languages, saying that the integration of human cells to pig skin was like two people aginh to communicate in Chinese and French, whereas the human cells in the process of aging macaque embryo were able to communicate like people speaking Spanish and French.
Biological theories of aging
This breakthrough development will help researchers gain a clearer understanding of molecular pathways, allowing for them to continue to improve the integration of human cells into more suitable hosts. Once scientists have developed a clearer understanding of molecular communication, chimeric organisms could allow unprecedented research into the earliest the process of aging of human development and cell regeneration. In addition, they could allow invaluable research into the development and progression of a variety of diseases, allowing for more effective treatments and cures to be developed. Another avenue into which researchers hope to gain insight is the aging process. As of now there is no conclusive information on the rate at which different organs age, or how the aging of one organ can impact the other, and Izpisau Belmonte hopes to change this.
Chimerism could allow researchers to grow the organ of an animal with a short life span in a much longer lived species in order to observe the rate at which the organ ages, and the way it affects the rest of the organs in the animal.]
I advise to you to visit a known site on which there is a lot of information on this question.
Excuse, that I interfere, but, in my opinion, this theme is not so actual.