bipolar disorder articles.
Worldwide, 1 in 4 people will suffer from a depressive episode in their lifetime. While current diagnosis click treatment approaches are largely trial and error, a breakthrough study by Indiana University School of Medicine researchers sheds new light on the biological basis of mood disorders, and offers a promising blood test artticles at a precision medicine approach to treatment.
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Led by Alexander B. The work builds on previous research conducted by Niculescu and his colleagues into blood biomarkers that track suicidality as well as pain, post-traumatic stress disorder and Alzheimer's disease. This study represents a current state-of-the-art outcome of our efforts," said Niculescu.
To bipolar disorder articles it become like other contemporary fields such as oncology. Ultimately, the mission is to save and improve lives.
What is bipolar disorder?
The team's work describes the development of a blood test, composed of RNA biomarkers, that can distinguish how severe a patient's depression is, the risk of them developing severe depression in the future, and the risk of future bipolar disorder manic-depressive illness. The test also informs tailored medication choices for patients. This comprehensive study took place bipolar disorder articles four years, with over participants recruited primarily from the patient population at the Richard L. The team used a careful four-step approach of discovery, prioritization, validation and testing.
First, the participants were followed over time, bipolar disorder articles researchers here them in both high and low mood states -- each time recording what changed in terms of the biological markers biomarkers in disorrer blood between the two states.
Next, Niculescu's team utilized large databases developed from all previous studies in the field, to cross-validate and prioritize their findings. From here, researchers validated the top 26 candidate biomarkers in independent cohorts of clinically severe people with depression or mania.
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Last, the biomarkers were tested in additional independent cohorts to determine how strong they were at predicting who is ill, and who will become ill in the future. From this approach, researchers were then able to demonstrate how to match patients with medications -- even finding a new potential medication to treat depression. These blood tests can open the door to precise, personalized matching with medications, and objective monitoring of response to treatment. In addition to the bipolar disorder articles and therapeutic advances discovered in their latest study, Niculescu's team found that mood disorders are bipolar disorder articles by circadian clock genes -- the genes that regulate seasonal, day-night and sleep-wake cycles.
According to Niculescu, the work done by his team has opened the door for their findings to be translated into clinical practice, as well as help with new drug development.
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Focusing on collaboration with pharmaceutical companies and other doctors in a push to start applying some of their tools bipolar disorder articles discoveries in real-world scenarios, Niculescu said he believes the work being done by his team is vital in improving the quality of life for countless patients. The brain cannot be easily biopsied in live individuals, so we've worked hard over the years to identify blood biomarkers for neuropsychiatric disorders," said Niculescu.
Materials provided by Indiana University School of Medicine. Note: Content may be edited for style and length. Science News. Journal Reference : H. Le-Niculescu, K.]
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