Cardiac collateral circulation Video
The Heart Secured by Collateral 1Cardiac collateral circulation - day, purpose
While data supports thrombectomy with CAS in tandem occlusions due to atherosclerosis, there is limited data on its safety and efficacy in tandem occlusions from carotid dissection. Marnat et al 4 examined the safety and outcome of CAS during the treatment of tandem occlusions from carotid dissections using pooled data from two prospectively maintained, multicenter databases Endovascular Treatment in Ischemic Stroke and Thrombectomy in Tandem Lesion. The analysis included patients who received endovascular therapy for tandem occlusions related to acute cervical carotid dissection between January and January The endovascular strategy, stenting protocol, and antithrombotic regimens were chosen by the interventionalist and treating team. Patients were divided in two groups depending on whether they did or did not undergo CAS. The main outcomes of favorable neurological outcome defined as day mRS and successful reperfusion modified Thrombolysis in Cerebral Infarction score 2b-3 were assessed in both groups. The rates of procedural complications, day mortality, and symptomatic intracerebral hemorrhage were also compared between patients who did and did not undergo CAS.
cardiac collateral circulation
Dis Model Mech 1 March ; 6 2 : — Angiogenic therapy, which involves the use of an exogenous stimulus to promote blood vessel growth, is an attractive approach for the treatment of see more diseases. It has been shown in animal models that the stimulation of blood vessel growth leads to the growth of the whole vascular tree, improvement of ischemic tissue perfusion and improved muscle aerobic energy metabolism.
However, very few positive results cardiac collateral circulation been gained from Phase 2 and 3 clinical angiogenesis trials. Many reasons have been given for the failures of clinical trials, including poor transgene expression in gene-therapy trials and collaterzl of the vessels induced by therapy.
Cardiac Artery Disease And Percutaneous Transluminal Coronary Angioplasty
In this Review, we discuss the selection of preclinical models as one of the main collaterap why clinical translation has been unsuccessful thus far. This issue has received little attention, but could have had dramatic implications on the expectations of clinical trials. We highlight crucial differences between human patients and animal models with regards to blood flow and pressure, as well as issues concerning the chronic nature of ischemic diseases in humans. We use cardiac collateral circulation as examples to demonstrate why the results from preclinical trials might have overestimated the efficacy of angiogenic therapies developed to date.
We also suggest ways in which currently available animal models of ischemic disease could be improved to better mimic human disease conditions, and offer advice on how to work with existing models link avoid overestimating the efficacy of new angiogenic therapies. Ischemic diseases make up a group of cardiac collateral circulation diseases that result from inadequate oxygenation of cardiqc such as the heart causing coronary artery diseasebrain cerebrovascular disease and peripheral muscles peripheral arterial disease.
Managing Tandem Occlusions From Carotid Dissection: To Stent or Not to Stent?
The principal pathophysiological process cardiac collateral circulation ischemic diseases is atherosclerosis. Atherosclerosis is a progressive disease that usually affects large collwteral, in which the accumulation of lipids, inflammatory cells and fibrous material in the inner arterial wall culminates in the formation of stenotic and occlusive lesions Lusis, Humans with significant stenosis of source arterial lumen experience reversible ischemic pain during exercise, which manifests as stable angina pectoris or intermittent claudication.
Progression of the stenosis is associated with ischemic pain at rest, which manifests as unstable angina pectoris or critical chronic limb ischemia. Acute and life-threatening cardiovascular events, such as myocardial infarction and stroke, can occur upon rupture coloateral an atherosclerotic lesion and subsequent atherothrombotic events. Treatment of ischemic diseases is strongly based on prevention of disease progression.]
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