How is obesity related to type 2 diabetes, hypertension, and heart disease? Video
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Click in mice has shown how a drug that is already used to treat heart disease can reverse obesity in mice, with no apparent side effects. The study, by scientists at the Spanish National Cancer Research Centre CNIOidentified the cytokine interleukin 17A ILA as a causal factor for obesity, and found that ILA acts directly on adipose tissue to cause obesity and associated metabolic syndrome, which can lead to disorders including type 2 diabetes, hypertension, and cardiovascular diseases. Digoxin administration also reversed obesity-related metabolic disorders. The researchers suggest that their study offers up a possible therapeutic strategy based on a novel approach: hypertension obesity by targeting its inflammatory component. It is well recognized that obesity is an inflammatory disease, effectively a chronic defensive reaction of the body to stress caused by excess nutrients.
Based on this knowledge, the team led by Djouder considered a potential therapeutic approach to obesity that would prevent inflammation. Evidence from other studies has previously indicated that nutrients can induce inflammation through a process mediated by ILA, the key component of inflammation. Digoxin has and heart disease? been used to treat heart failure, and is known to act on ILA. The researchers postulated that using digoxin to block the production of ILA by immTo test this out they how is obesity related to type 2 diabetes diet-induced obese DIO mice using various doses of digoxin.
The results confirmed that even while the obese animals continued to eat their high fat diet, digoxin administration was associated with read more weight loss, and metabolic improvements, which started within just a week of initiating treatment. Importantly, at the higher dose level, digoxin therapy completely restored glucose homeostasis, indicating that digoxin dose-dependently reduces features of metabolic syndrome, they further noted. But when digoxin therapy was withdrawn, the animals started to put weight back on.
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Djouder credited this to the fact that cardiovascular disease of patients using digoxin causes high liquid retention, which masks the weight-loss effect of digoxin. It might also be possible that it might be necessary to increase the digoxin dose in humans to induce weight loss.
And the fact that no side effects were observed in animals suggests that, in humans, the dose at which weight loss could be observed may not be harmful. The findings source have key clinical relevance, the authors suggest. The how is obesity related to type 2 diabetes acknowledged that check this out results were obtained in mice, and that epidemiological studies and clinical trials are required to corroborate them in hypertension. They further noted that in addition to the potential clinical relevance of their findings, the study has added value in that it identifies a causal link between inflammation and weight gain.
This opens new avenues for crucial research to elucidate the molecular mechanisms that make obesity an inflammatory disease. Understanding the connection between nutrient excess, inflammation and obesity is essential to find novel approaches to treat weight gain. As with anything you read on the internet, this article should not be construed as medical advice; please talk to your doctor or primary care provider before making any changes to your wellness routine.
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