Risk factors of multiple sclerosis Video
Breaking News: Zeroing in on risk factors for MSRisk factors of multiple sclerosis - are
Multiple Sclerosis MS is the second most common cause of non-traumatic neurological disability in young adults. It is an autoimmune inflammatory disease of the central nervous system, this means that it is a disease where the immune system starts attacking the brain, optic nerves, and spinal cord. Multiple Sclerosis is classified as a neurodegenerative disease. According to the most recent prevalence published in , nearly one million adults are living with MS in the United States. The average risk of developing MS is determined to be 3. risk factors of multiple sclerosisRisk factors of multiple sclerosis - really. All
Ocrelizumab safety outcomes have been well evaluated in clinical trials and open-label extension OLE studies. However, risk factors for infection in patients with multiple sclerosis MS receiving ocrelizumab have not been extensively studied in the real-world setting. The aim of this study was to examine factors determining risk of self-reported infections and antimicrobial use in patients receiving ocrelizumab for MS. A retrospective, observational cohort study was conducted in patients receiving ocrelizumab at the Royal Melbourne Hospital. Infection type and number were reported by patients, and the associations of potential clinical and laboratory risk factors with self-reported infection and antimicrobial use were estimated using univariate and multivariable logistic regression models. A total of patients were included in the study; a total of infections were reported in 89 patients In univariate analyses, a higher serum IgA was associated with reduced odds of infection OR 0. In multivariable analyses, older age OR 0.The presence of cardiovascular risk factors in patients with multiple sclerosis MS is associated with a greater degree of brain atrophy even in young patients who are unlikely to have small vessel disease, a new study has shown. Bonacchi said. We found a synergistic effect of the different risk factors. Previous studies have not set an age limit for examining this relationship and they have also assessed the presence versus absence of cardiovascular risk factors, without attempting to grade the strength of exposure, he noted.
For the current study, the researchers examined several cardiovascular risk factors and in addition to just being risk factors of multiple sclerosis or absent. They also graded sclegosis risk factor as being stringent or not depending on a certain threshold.
Key Points
For example, smoking was defined as a threshold of 5 pack-years smoking 5 cigarettes a day for 20 risk factors of multiple sclerosis or 20 cigarettes a day for 5 years. And the more stringent definition was 10 pack-years. For hypertensionthe stringent definition was consistently high blood pressure levels and use of antihypertensive medication, with similar definitions used for cholesterol and diabetes.
This was a cross-sectional observational study in patients with MS and 95 healthy controls. Results were adjusted for age, sex, disease duration, phenotype relapsing-remitting versus progressive MS and treatment. Results showed no significant difference if patients were exposed to at least one classical risk factor versus no risk factors.
But if a patient had kultiple least two classical risk factors, significant differences were found in gray matter, white matter, and total brain volume. Bonacchi reported.
Associated Data
Healthy controls showed no differences in any of the brain volume outcomes in those with or without cardiovascular risk factors. Bonacchi suggested. Skip to main content. Conference Coverage.
Vascular Disease Risk Factors and Multiple Sclerosis
Cardiovascular risk factors linked to brain atrophy in MS. Publish date: September 12, By Sue Hughes. Pages 1 2 last ». Multiple Sclerosis.]
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