Stoner mucus Video
Jimmy Kimmel Interviews Stoner from MichiganRemarkable question: Stoner mucus
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stoner mucus
Distribution
When homeostasis of airway hydration and ciliary function are lost, lung diseases such as chronic obstructive pulmonary disease COPD develop Wiegman et al. COPD is highly prevalent worldwide, comprising airspace enlargement and airway remodeling that lead stoner mucus significant airflow limitations in patients Vestbo et al.
Cigarette smoke exposure leads to cellular dysfunction, including changes in mitochondrial metabolism Hoffmann et al. Discovery-based studies in search of unrealized, essential biology are difficult to conduct in the complex tissue of the human lung.
In the search of new mucud for addressing COPD pathogenesis, we leveraged the social amoeba Dictyostelium discoideum to identify genetic protectors from cigarette smoke. We used an expression cDNA library suppression approach with follow-up in primary human airway epithelial cells. We discovered that overexpression of canonical inner mitochondrial stoner mucus transport proteins, i.
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This finding is important as mitochondrial dysfunction has been linked to airway remodeling in COPD Wiegman et al. There are four ANT paralogs in human — i. In other disease scenarios, ANT1 deficiency stoner mucus in hypertrophic cardiomyopathy, myopathy and lactic acidosis Graham et al.
Reduction in levels of ANT2 also stoner mucus adipocytes from hypoxia and inflammation Seo et al. Moreover, we found that ANT2 also plays an important role in airway epithelial biology, notably airway hydration, which promotes ciliary function.
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We found that ANT proteins are distributed at the apical plasma membrane of airway epithelial cells. Moreover, we found that ANT2, in particular, interacts with the chemiosmotic circuit that controls airway hydration, facilitating robust ciliary beating. To identify potential genetic protectors against cigarette smoke, we utilized the model organism Dictyostelium as a tool to identify genes that could then be directly studied in human and mouse models of lung disease Fig. We then isolated stoner mucus plasmids from stoner mucus winner cells and reintroduced them into fresh Dictyostelium cells to confirm the suppression effects. Because the ancA plasmid was the strongest protector, ANT became the focus of this study.]
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