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Nitroglycerin mechanism of action

nitroglycerin mechanism of action

Jul 22,  · Nitroglycerin, an organic nitrate, is a vasodilating agent. The chemical name for nitroglycerin is 1, 2, 3 propanetriol trinitrate and the chemical structure is: C 3 H 5 N 3 0 9. Molecular weight: Nitroglycerin Sublingual Tablet - . Contraindications. Early myocardial infarction, severe anemia, increased intracranial pressure, and known hypersensitivity to nitroglycerin. Recent use (within several days) of PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, or vardenafil) may cause dangerously low hypotension; the time course of the interaction appears to be related to the PDE-5 inhibitor half-life. mechanism of action Similar to other nitrites and organic nitrates, nitroglycerin is converted to nitric oxide (NO), a reactive free radical. Nitric oxide, the active intermediate compound common to all agents of this class, activates the enzyme guanylate cyclase, thereby stimulating the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP).

Nitroglycerin mechanism of action Minor Nitroglycerin can cause hypotension.

nitroglycerin mechanism of action

Nitroglycerin may enhance the hepatic clearance of alteplase more info alteplase plasma concentrations are lower in patients receiving concomitant nitroglycerin. Download as PDF Printable version. Fenoldopam: Moderate Concomitant use of nitrates with other antihypertensive agents can cause additive hypotensive effects.

nitroglycerin mechanism of action

Procaine: Moderate Local anesthetics may cause additive hypotension in combination with antihypertensive agents. Quazepam: Minor Nitroglycerin can cause hypotension.

nitroglycerin mechanism of action

Irrespective of the route of administration, organic nitrates are virtually completely metabolized by the enzyme glutathione-organic nitrate reductase, so the systemic or presystemic hepatic biotransformation is the key determinant of the bioavailability and duration of action of the various preparations. Reserpine: Moderate Concomitant use of nitrates with other antihypertensive agents can cause additive hypotensive effects. Memorie della Reale Accademia delle Scienze di Torino.

IUPAC name 1,3-dinitrooxypropanyl nitrate; [3- nitrooxy nnitroglycerin nitrooxy methyl]propyl] nitrate; 1,2,3-trinitroxy propane. Retrieved if October S2CID Views Read Edit View history. Journal link Obstetrics click Gynaecology Canada. Other Oral Formulations. Clonazepam: Minor Nitroglycerin can cause hypotension.

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This action may be additive with other agents nitroglycerin mechanism of action can cause hypotension such as diuretics. Minor Nitroglycerin can cause hypotension.

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Nitroglycerin and Nitrates - Mechanism of Nitrroglycerin, Indications, and Side Effects