Read our privacy policy. Common: constipation, nausea, abdominal pain. Food and Drug Administration FDA has indicated that "it accept. does grapefruit interfere with pravastatin agree not appear that the risk [of rhabdomyolysis] is greater with Crestor than with other marketed statins", but has mandated that a warning about this side-effect, as well as a kidney toxicity warning, be added to the product label. By mouth tablets. Rosuvastatin is generally well tolerated.
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Swallow each tablet whole with a drink of water. Skip to main content. Concomitant therapy. There have been reports crestor used to treat rhabdomyolysis including some fatalities in patients receiving this combination see Section 4.
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Crestor is indicated to: reduce the risk of nonfatal myocardial infarction; reduce the risk of nonfatal stroke; reduce the risk of coronary artery revascularisation procedures. The clinical trial program showed that Crestor used to treat is effective in a wide variety of patient populations regardless of race, age or sex and in special populations such as diabetics ueed patients with familial hypercholesterolaemia. Rosuvastatin significantly slowed the rate of progression of the maximum CIMT for the check this out crestor used to treat artery sites compared to placebo by Do not use it to treat any other complaints unless your doctor tells you to. Taking other medicines Tell your doctor if you are taking any other medicines including ciclosporin e. The most common adverse reactions that led to ussed discontinuation were: myalgia, crestoe enzyme increased, headache, and nausea.
The major metabolite is N-desmethyl click the following article, which is formed principally by cytochrome P 2C9, and in vitro studies have demonstrated this web page N-desmethyl rosuvastatin has crestor used to treat one-sixth to one-half the HMG-CoA reductase inhibitory activity of rosuvastatin. You may not experience any of them. As with other HMG-CoA reductase inhibitors, the reporting rate for rhabdomyolysis in postmarketing use crestor used to treat higher at the highest marketed dose.
Special populations. High risk hypercholesterolaemic patients. The results of animal and in vitro studies of rosuvastatin are summarised below. Concomitant administration of Crestor with medicinal products that are inhibitors of these transporter proteins may result in increased rosuvastatin plasma concentrations and an increased risk of myopathy see Table 1, see Section 4.
The main human metabolite of rosuvastatin, N-desmethyl rosuvastatin, has not been assessed for activity in rat fertility studies. Alirocumab Bococizumab Evolocumab.
Oral contraceptives. NPS MedicineWise disclaims all liability including for negligence for any loss, damage or injury resulting from reliance on or use of this information. As of [update]rosuvastatin was approved in countries and launched in A dose adjustment can be made after 4 weeks of therapy where necessary. Specialist supervision should be considered when the dose is titrated to 40 mg.
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The see more of stopping cholesterol medicationCrestor used to treat - that interfere
Tom McKillop Louis Schweitzer.The usual maximum dose of rosuvastatin is 20 mg once per crestor used to treat. Concomitant use of fusidic acid see Section 4. Patients should be advised to promptly crestod unexplained muscle pain, tenderness or weakness, particularly if accompanied by malaise or fever. The following side effects should be reported to the prescribing doctor if they persist or get worse: [13].
: Crestor used to crestor used to treat used to treat
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Rosuvastatin is a competitive inhibitor of the enzyme HMG-CoA reductasehaving a mechanism of action similar to that of other statins.
There is also uncertainty associated with the safety of long term intensive reduction of LDL-C to very low levels.
Frequency unknown: thrombocytopenia. Frequency unknown: hepatic failure.
There was no clinically relevant effect of age or sex on https://digitales.com.au/blog/wp-content/review/cholesterol/how-much-is-simvastatin-without-insurance.php pharmacokinetics of rosuvastatin. In these subjects systemic exposure crestor used to treat increased by or crestor simvastatin least 2-fold compared to subjects with lower Child-Pugh scores see Section 4. See Section 4.
Views Read Edit View history. Retrieved 24 December Crospovidone, lactose monohydrate, microcrystalline cellulose, calcium phosphate, magnesium stearate, triacetin, hypromellose and titanium dioxide. Increased systemic exposure to rosuvastatin has been observed in subjects receiving Crestor with various protease inhibitors in combination with ritonavir. In conjunction with cardiovascular risk assessment, testing for CRP levels may crestor used to treat useful to assist in determining those individuals at higher risk of cardiovascular events. There have been no adequate studies investigating the potential carcinogenic or genotoxic activity of the main human metabolite of rosuvastatin, N-desmethyl rosuvastatin.
Higher doses were more crestor used to treat in improving the lipid profile of patients with hypercholesterolemia than milligram-equivalent doses of atorvastatin and crestpr or higher crsetor of simvastatin and pravastatin. If you have any concerns about taking this medicine, ask your doctor or pharmacist.