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There have been rare reports of reversible memory loss and confusion with all statins, including atorvastatin; however, there has not been enough evidence to associate statin use with cognitive impairment, and what is lipitor atorvastatin used for risks for cognition are likely outweighed by the beneficial effects of adherence what is lipitor atorvastatin used for statin therapy on cardiovascular and cerebrovascular disease. Discontinuation and withdrawal of Atorvastatin Lipitor. Lipid-modifying agents C Retrieved 31 July Retrieved 16 October Winslow R 24 January Financial Times. Subscribers may share up to atorvastahin or 20 articles per month using the gift article service.
General guidelines advise that if therapy is discontinued, a patient be prescribed treatment with the same medication at a later time or a different statin medication may be used in its place. April A few cases of myopathy have been reported when atorvastatin is given with colchicine.
Retrieved 24 November American Journal of Cardiology. Interactive image.
Simple. Atorvastatin.
The liver is the primary site of action of atorvastatin, as this is the principal site of both cholesterol synthesis and LDL clearance. There does not appear to be any entero-hepatic recirculation. This interaction was tested in vitro with concurrent visit web https://digitales.com.au/blog/wp-content/review/cholesterol/does-zetia-make-you-gain-weight.php of erythromycina known CYP3A4 isozyme inhibitor, which resulted in increased plasma concentrations of atorvastatin.
International Urology and Nephrology. S2CID Drug Discovery Today.
Alternate day dosing more info be carefully considered by a treating doctor as the lipid lowering capability is limited — meaning that lipid lowering percentages will be less than that of a daily dose. BMC Medicine. Early results comparing atorvastatin what is lipitor atorvastatin used for simvastatin demonstrated that atorvastatin appeared more potent and with fewer side effects.
As a substrate for the CYP3A4 isozyme, it has shown susceptibility to inhibitors and inducers of CYP3A4 to produce increased or decreased plasma concentrations, respectively. Niacin also is proved to increase the risk of myopathy or rhabdomyolysis. In people with acute coronary syndromehigh-dose atorvastatin treatment may play a plaque-stabilizing role.
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January Retrieved 3 April Retrieved 26 October
Retrieved 18 November Help Learn to edit Community portal Recent changes Upload file. November - December This interaction was tested in vitro with concurrent administration of erythromycina known CYP3A4 isozyme inhibitor, which resulted in increased plasma concentrations of atorvastatin. Lipitor, the cholesterol-lowering medication, has become the bestselling pharmaceutical in history. Retrieved 10 May