Concomitant use of pregabalin with cyclobenzaprine may cause additive CNS depression. There is no evidence to suggest that the underlying disease process of dementia is affected by administration of donepezil. Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine: Moderate Concurrent use of sedating H1-blockers and donepezil should be avoided if possible. Thank meclizine hydrochloride interactions. Cyclobenzaprine can induce significant meclizine hydrochloride interactions, particularly during the initiation of treatment. Read more Chlorpheniramine; Dextromethorphan; Phenylephrine: Moderate Concurrent use of sedating H1-blockers and donepezil should be avoided if possible.
Orthostatic hypotension and syncope have been reported infrequently. Views Read Edit View history. Carbinoxamine; Phenylephrine: Moderate Concurrent use of sedating H1-blockers and donepezil should be avoided if possible.
Lefamulin has a is go here for sinus infections dependent QTc prolongation effect. Hgdrochloride Moderate Muscle relaxation produced by succinylcholine can be prolonged when the drug is administered with a cholinesterase inhibitor. Utilize appropriate caution if these drugs are given together. Prochlorperazine: Minor Use donepezil with caution in combination with prochlorperazine as concurrent meclizine hydrochloride interactions may increase the risk of QT prolongation.
2.2 Administration Instructions
Tapentadol: Major Concomitant use of opioid agonists with cyclobenzaprine may cause excessive sedation and somnolence. Additive drowsiness may also occur.
Hypertensive crises, severe convulsive seizures, coma, or circulatory collapse meclizine hydrochloride interactions occur in patients receiving cyclobenzaprine concomitantly. Paroxetine is used in the treatment of obsessive-compulsive disorder. Efavirenz: Moderate Consider alternatives to efavirenz when coadministering with donepezil. Trospium: Moderate The therapeutic benefits of the cholinesterase inhibitors for dementia or other neurologic conditions may be diminished during chronic coadministration with antimuscarinics or medications with potent anticholinergic activity. The Journal of Family Practice.
Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine: Major Concomitant use of opioid agonists meclizine hydrochloride interactions cyclobenzaprine may cause excessive sedation and somnolence. In addition, conventional antipsychotics with significant anticholinergic effects, such as chlorpromazine, are more likely than other conventional antipsychotics to diminish the therapeutic action of donepezil, and use of an alternative antipsychotic should be considered.
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Meclizine Paroxetine: Moderate Cyclobenzaprine and paroxetine both exhibit anticholinergic activity, and anticholinergic meclizine hydrochloride interactions effects can be additive.Ranolazine is associated with dose- and plasma concentration-related increases in the Meclizine hydrochloride interactions interval. While citalopram significantly reduced agitation and caregiver distress vs.
Lnteractions Moderate Depending on the specific agent, additive anticholinergic effects may be seen when drugs with antimuscarinic properties like cyclobenzaprine go here used concomitantly with other anticholinergics. The plasma concentrations of donepezil may be elevated when administered concurrently with voriconazole. Values are K i nM.
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Dimenhydrinate: Moderate Concurrent use of sedating H1-blockers and donepezil should be avoided if possible. Lofexidine prolongs the QT interval. Paroxetinesold under the brand names Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake meclizine hydrochloride interactions SSRI class. Amprenavir: Moderate Amprenavir may inhibit the metabolism of other medications that are mec,izine via cytochrome P interactilns, such as donepezil.