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Although the rapid discovery of small molecules from plant and microbial origin with enhanced bioactivity has provided us with some hope, a rapid hike in the resistivity of superbugs has proven to be the biggest therapeutic hurdle of all times. Moreover, several distinct mechanisms endowed by these notorious superbugs make them immune to these antibiotics subsequently causing our antibiotic wardrobe to be obsolete. Herein, we also discuss multidimensional strategies to combat antimicrobial resistance. Keywords: antibiotic therapy, antibiotic-binding proteins, antimicrobial resistance, drug delivery systems, drug repurposing, pharmacodynamics, receptors 1. Introduction 1. Superbugs The modern era has observed a worldwide explosion and tremendous upsurge in notorious, opportunistic, and recalcitrant superbugs that are highly resistant to antibiotics, 1 , 2 and are the virulent cause of infections in humans and animals. Bacteria are champions of evolution, and their frequently observed antibiotic resistance is due to the acquisition of resistant genes laterally from the environment, 5 and incorporating them either in their plasmid or their genome. The environment harbors plenty of DNA from dead cadavers and these opportunistic pathogens are voracious grave eaters. Moreover, a glycopeptide antibiotic, vancomycin, with its target in preventing peptidoglycan synthesis of the cell envelope in Gram-positive bacteria, such as enterococci, streptococci, and staphylococci proved obsolete because of the presence of vancomycin resistant plasmids in these pathogens.Magnificent idea: Sesquiterpenes blood brain barrier
| Sesquiterpenes blood brain barrier | Sep 13, · Quote: How do you use essential oils internally? There are many ways to use essential oils internally. –You can add a drop of oil to a glass of water or a teaspoon of honey. For example, a drop of lemon will make your water taste great. A drop of peppermint will taste good and ease stomach. 2 days ago · Learn all about our new Drug Allergy Module for our Clinical API! Read Now! 10 hours ago · digitales.com.au "No one can serve two masters" (Matthew ) Main menu. Skip to content. |
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