Gene therapy for ms Video
A level. R.7. Cystic fibrosis and gene therapy (Ms Cooper)Gene therapy for ms - sorry
In order words in patients with multiple sclerosis, the body turns on itself, launching an immune system attack that destroys the myelin sheath, which is a protective membrane coating that wrap around the axon of nerve cells in the central nervous system, leaving them exposed like bare wires. Similar to exposed electrical lines, the unprotected nerve fibers touch and short out, leading to the neurodegenerative effects that are a hallmark of multiple sclerosis. The nerve damage is caused by inflammation, which leads to loss of the oligodendrocytes cells that produce myelin that form the electrical insulation around the axons of CNS nerve cells. Symptoms of MS vary, because the location and severity of each attack can be different muscle, GI, optical, speech, inflammations, brain and nerve symptoms Houtchens MK et al. Stem Cell Therapy for MS[ edit edit source ] Stem Cells are Cells with the ability to divide for indefinite periods in culture and to give rise to specialized cells. gene therapy for msKesimpta is a targeted, precisely dosed and https://digitales.com.au/blog/wp-content/custom/japan-s-impact-on-japan/hgps-syndrome.php B-cell therapy that has shown superior efficacy with a similar safety profile compared with teriflunomide, a first-line treatment in MS2. Kesimpta is a testament to our commitment to reimagine medicine and we remain dedicated to helping to improve the lives of people living with this disease.
It is an anti-CD20 monoclonal antibody mAb self-administered by a once-monthly injection, delivered subcutaneously2,3. Initial doses of Kesimpta are at Weeks 0, 1 and 2, with the first injection performed under the guidance of a healthcare professional. As shown in preclinical studies, Kesimpta is thought to work by binding to a distinct epitope on the CD20 molecule inducing potent Tjerapy lysis and depletion5.
The selective mechanism of action and subcutaneous administration of Kesimpta allows precise delivery to the lymph nodes, where B-cell depletion in MS is needed, and preclinical studies have shown that it may preserve the B-cells in the spleen6. Once-monthly dosing of Kesimpta differs from other anti-CD20 therapies as it allows faster repletion of B-cells, offering more flexibility in MS management7. Ofatumumab was originally developed by Genmab and licensed to GlaxoSmithKline.
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